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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On 18 February 2019, Elizabeth Phillips from Cancer Research UK and University College London Cancer Trials Center, London, UK and colleagues, published in Leukemia & Lymphoma the results of a phase I trial investigating the efficacy and safety of alemtuzumab and cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) combination for the treatment of aggressive T-cell lymphoma.
Despite the low long-term survival rates with CHOP, it remains the standard of care for most aggressive T-cell lymphomas. In this phase I, dose escalation trial, the authors investigated the possibility of combining CHOP chemotherapy with alemtuzumab, as a potential regimen against aggressive T-cell lymphoma. Alemtuzumab is a monoclonal, humanized, anti-CD52 antibody that has been used as monotherapy in cases of T-cell prolymphocytic leukemia and relapsed or refractory (R/R) T-cell lymphoma. The primary endpoint of this study was to assess the toxicity of the combination treatment and establish a maximum tolerated dose (MTD) for alemtuzumab. Secondary endpoints, included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).
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