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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On Sunday 3rd June an oral abstract session took place at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting. Abstract 7502 was presented by William Wierda, The University of Texas MD Anderson Cancer Center, Texas, on the phase II CAPTIVATE study (NCT02910583).
The study assessed the use of ibrutinib plus venetoclax as first-line treatment in chronic lymphocytic leukemia (CLL). A total of 164 patients with treatment-naïve CLL were included in the trial. They were treated with 420mg ibrutinib once daily for 3 cycles and then intravenous venetoclax up to 400mg once daily for 12 cycles. If minimal residual disease (MRD) was confirmed detectable then patients were randomized to receive either placebo or ibrutinib. If MRD was undetectable, not confirmed then patients were randomized to receive either ibrutinib or ibrutinib plus venetoclax (I+V).
Dr Wierda concluded that “these early results show a highly active and safe treatment with 12 cycles of combined treatment with ibrutinib and venetoclax.” See below for an interview with Dr Wierda discussing the study results.
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