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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On April 1, 2022, it was announced that the U.S. Food and Drug Administration (FDA) had granted approval to the chimeric antigen receptor (CAR) T-cell therapy axicabtagene ciloleucel (axi-cel) for adult patients with large B-cell lymphoma (LBCL) who have relapsed within 12 months of, or who are refractory to, first-line chemoimmunotherapy.1 This change in authorization could expand the pool of those eligible for CAR T-cell therapy by up to 11,000 patients in the U.S. alone.1 LBCL is the most commonly diagnosed form of non-Hodgkin lymphoma globally.2
The approval is based on key data obtained from the ZUMA-7 trial.
This approval could help to address an area of unmet need for patients with LBCL who do not respond well to high-dose chemoimmunotherapy.
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