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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On 10 January 2019, Ramon Garcia-Sanz from University Hospital Salamanca, Salamanca, SP and colleagues, published in Annals of Oncology the long-term results of a phase I-II trial performed by the Spanish GELTAMO group (NCT02243436).
In this phase I-II trial the efficacy and safety of brentuximab vedotin (BV) in combination with etoposide, solumedrol, high-dose AraC, and cisplatin (ESHAP; BRESHAP) were investigated as second line treatment for relapsed or refractory (R/R) Hodgkin lymphoma (HL) patients. The initial analysis of this trial was published in Blood (2016). The primary endpoints of this long-term follow-up analysis were overall and complete response prior autologous stem cell transplantation (ASCT), as well as maximum tolerable dose (MTD). Secondary endpoints included overall survival (OS), progression-free survival (PFS), and time-to-tumor progression (TTP).
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