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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On 10 January 2019, Anna Dodero and Anna Guidetti from the Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, IT, and colleagues published in Leukemia a retrospective study investigating the efficacy and safety of etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (DA-EPOCH-R) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in double-hit diffuse large B-cell lymphoma (DLBCL) patients.
In this retrospective study the outcomes of DLBCL double expressors were compared after DA-EPOCH-R or R-CHOP treatment, which was administered in a similar period in three different Italian institutions. The primary endpoints of this study were progression-free survival (PFS), and overall survival (OS). Secondary endpoints included survival comparisons according to different subgroup analyses (age, genetic abnormalities etc.).
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