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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On 1st June 2018, a paper on the efficacy and safety outcomes of immunochemotherapy with obinutuzumab (G) or rituximab (R) in previously untreated follicular lymphoma (FL) was published in the Journal of Clinical Oncology by Wolfgang Hiddemann, University Hospital, Ludwig Maximilian University, Munich, and colleagues.
The safety and efficacy analysis came from results of the GALLIUM study (NCT01332968) that compared R and G combined with either cyclophosphamide (C), doxorubicin, vincristine (V) and prednisone (P) (CHOP), CVP or bendamustine.
The authors concluded that there was improved efficacy with the G plus chemotherapy treatment arm in patients with previously untreated FL. They noted that cytopenias were reported more frequently with CHOP chemotherapy and more severe infections were reported with bendamustine chemotherapy. Finally, the authors recommended that first-line therapy and subsequent chemotherapy should be considered individually for each patient.
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