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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On December 21, 2022, it was announced that loncastuximab tesirine, a CD19-targeted antibody–drug conjugate, received approval from the European Commission (EC) for the treatment of adult patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL); it marks a major clinical development for patients across Europe with DLBCL.1
This approval is based on key results from the phase II LOTIS-2 trial (NCT03589469), in which loncastuximab tesirine demonstrated durable responses in heavily pretreated patients with R/R DLBCL following ≥2 prior lines of systemic therapy.
Moreover, this follows the recent positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in September. Prior to this, the U.S. Food and Drug Administration (FDA) granted its approval for this patient subset in April 2021.
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