All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
The Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
On October 1, 2020, the U.S. Food and Drug Administration (FDA) granted fast track designation to CLBR001 + SWI019, a novel ‘switchable’ chimeric antigen receptor (CAR) T-cell therapy currently being evaluated for the treatment of patients with B cell malignancies, including non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL).1
CLBR001 + SWI019 is a combination therapy comprising an autologous CAR T-cell product (CLBR001) and an anti-CD19 antibody (SWI019), which acts as a molecular switch that controls the activity of the CAR T-cell. This approach has the potential to confer a significant safety advantage, and a first-in-human, phase I, dose-escalation study (NCT04450069) is currently recruiting patients diagnosed with relapsed or refractory B cell malignancies to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of CLBR001 + SWI019.
This novel combination immunotherapy may alleviate side effects which have hampered CAR T-cell therapy to date and, by employing a universal design, its future application could reach beyond B cell malignancies to other blood and solid tumor cancers.
Understanding your specialty helps us to deliver the most relevant and engaging content.
Please spare a moment to share yours.
Please select or type your specialty
Subscribe to get the best content related to lymphoma & CLL delivered to your inbox