How do you approach the treatment of untreated DLBCL?

During the Society of Hematologic Oncology (SOHO) 2021 Annual Meeting, the Lymphoma Hub was pleased to speak to Jason Westin, MD Anderson Cancer Center, Houston, US. We asked, How do you approach the treatment of untreated diffuse large B-cell lymphoma (DLBCL)?

Westin begins by highlighting the advantages of the international prognostic index but finds that it does not aid in selecting treatment for patients ineligible for R-CHOP. Westin outlines situations in which he would deviate from R-CHOP, including high international prognostic index and certain disease subtypes. He discusses future treatments such as circulating tumor DNA and the POLARIX trial investigating Pola-R-CHP. Finally, he predicts that in the future disease definitions of subtype, in terms of response to therapy, will need to improve.