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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On 5 April, 2022, it was announced that the European Commission (EC) granted marketing authorization for lisocabtagene maraleucel (liso-cel) for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma, primary mediastinal large B-cell lymphoma, and follicular lymphoma Grade 3B after ≥2 lines of systemic therapy.
Liso-cel is a CD19-directed chimeric antigen receptor (CAR) T-cell therapy with a 4-1BB costimulatory domain, administered as a defined composition to reduce variability in the CD4 and CD8 component dose. The approval is based on pivotal data obtained from the TRANSCEND WORLD, PLATFORM, OUTREACH and TRANSCEND-NHL-001 clinical trials. In addition to its efficacy in treating relapsed or refractory large B-cell Lymphoma, liso-cel has demonstrated a manageable safety profile in these patient groups.
This cell therapy has previously been approved by the U.S. Food and Drug Administration (FDA) and the Japanese Ministry of Health, Labor, and Welfare.
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