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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On 19 February 2019, Alexandre Hirayama from the Fred Hutchinson Cancer Research Center, Seattle, WA, USA, and colleagues, published in Blood results from multivariate analyses on factors affecting outcomes and survival in aggressive non-Hodgkin lymphoma (NHL) patients receiving CAR T-cell therapy.
Chimeric antigen receptor T cells (CAR-T) have opened up a new therapeutic avenue for relapsed or refractory (R/R) NHL patients, thus identifying factors that could be associated with even longer remissions after CD19 CAR T-cell therapy is crucial. In this phase I-II trial (NCT01865617), the authors performed a series of multivariate analyses in order to investigate various factors impacting the response rates and progression-free survival (PFS) of aggresive NHL patients, who had received CD19 CAR-T cells.
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